TC-A 2317 hydrochloride

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

TC-A 2317 盐酸盐是 Aurora 激酶 A 的抑制剂，Ki 为 1.2 nM，而 Aurora 激酶 B 的 Ki 为 101 nM。 TC-A 2317 盐酸盐具有抗肿瘤活性。

TC-A 2317 hydrochloride is an inhibitor of Aurora kinase A with a Ki of 1.2 nM compared to Aurora kinase B with a Ki of 101 nM. TC-A 2317 hydrochloride shows antitumor activity.(In Vivo):In rats, TC-A 2317 hydrochloride (30 mg/kg;p.o.) shows good PK profile; Cmax value is 4930 nM (Tmax=1.2 h) and serum concentration after 24 h is 52 nM (T1/2=3.3 h). In the antitumor mice model, TC-A 2317 hydrochloride is effective without a decrease of body weight.

TC-A 2317 hydrochloride (Compound 6) inhibits proliferation of HCT116 cells with an IC50 of 115 nM.

TC-A 2317 hydrochloride is effective in antitumor mice model without decrease of body weight.TC-A 2317 hydrochloride shows good PK profile; Cmax value is 4930 nM (Tmax=1.2 h) and serum concentration after 24 h is 52 nM (T1/2=3.3 h) at 30 mg/kg po in rats. Animal Model:HCT-116 Xenograft mice mode Dosage:P.o.; daily for 14 days Administration:30 mg/kg Result:Growth of tumor was inhibited by 59% after 14 days.

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Others

Other Targets

GluR

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1245907-03-2

392.93

C19H29ClN6O

>98% (HPLC)

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Cl.CC(CCCC(C)(C)O)Nc1nc(Nc2cc(C)[nH]n2)cc(C)c1[N+]#[C-]

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(-20℃)

With Ice Pack

≥ 2 years